What Is Optune Lua?

An innovative approach for treating mNSCLC after progression on or after platinum-based therapy1

Designed to fit into your patient’s everyday life

Using arrays adhered to the skin, electrical fields—known as tumor treating fields (TTFields)—are continuously delivered directly to the NSCLC tumor site1,*

 

  • Optune Lua is small and lightweight, at just 2.7 lbs (with battery)1,2
  • Wearable and portable for use during normal daily activities1
  • Designed for enhanced carrying comfort and usability1

*Effect is enabled when device is powered; transducer arrays should be charged at least 2 times per week (every 4 days at most).1

Optune Lua is intended for use of ≥12 hours a day on average1 
 

  • Data from previous studies with TTFields have established a positive correlation between improved survival outcomes and higher durations of usage1
  • Patients have the flexibility to decide which times of the day work best for them to use Optune Lua

In the LUNAR study1:

 

  • The majority of patients maintained an average monthly Optune Lua usage of 12+ hours per day, with a median of ~13 hours per day
  • Nearly 1 in 4 patients were able to achieve an average monthly usage of 18+ hours per day

Explore the Optune Lua system

The complete system includes a portable electrical field generator, transducer arrays, rechargeable batteries, and more1,3

Other components include3:
 

  • Portable batteries: 4 batteries are provided with each kit; each battery lasts for about 1 hour
  • Charger for portable batteries: Batteries will need to be recharged for 2 to 4 hours. The batteries can be charged and used many times for about 6 to 9 months
  • Plug-in power supply and power cords: "No-Stop Swap" enables patients to swap batteries or power source without disrupting delivery of TTFields

Optune Lua uses electric fields to disrupt cancer cell viability1

Learn more about the TTFields MOA

mNSCLC, metastatic non–small cell lung cancer; NSCLC, non–small cell lung cancer.

 

References: 1. Optune Lua for Non-Small Cell Lung Cancer (NSCLC). Physician Instructions for Use. Novocure; 2024. 2. Leal T, Kotecha R, Ramlau R, et al. Supplementary appendix. Lancet Oncol. 2023;24(9):1002-1017. Accessed March 21, 2024. https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(23)00344-3/fulltext 3. Optune Lua. Patient Information and Operation Manual for Non-Small Cell Lung Cancer. Novocure; 2024. 

Important Safety Information 

Contraindications 

Do not use Optune Lua® in patients with an electrical implant. Use of Optune Lua together with electrical implants has not been tested and may lead to malfunctioning of the implanted device. 

 

Do not use Optune Lua in patients known to be sensitive to conductive hydrogels. In this case, skin contact with the gel used with Optune Lua may commonly cause increased redness and itching, and rarely may even lead to severe allergic reactions, such as a fall in blood pressure and breathing difficulty.

Warnings and Precautions 

Optune Lua can only be prescribed by a healthcare provider that has completed the required certification training provided by Novocure® (the device manufacturer). 

 

Do not prescribe Optune Lua for patients who are pregnant, whom you think might be pregnant, or who are trying to get pregnant, as the safety and effectiveness of Optune Lua in these populations have not been established. 

 

The most common (≥10%) adverse events involving Optune Lua concurrent with PD-1/PD-L1 inhibitors or docetaxel were dermatitis, musculoskeletal pain, fatigue, anemia, dyspnea, nausea, cough, diarrhea, anorexia, pruritus, leukopenia, pneumonia, respiratory tract infection, localized edema, rash, pain, constipation, skin ulcers, and hypokalemia. 

 

Other potential adverse effects associated with the use of Optune Lua include treatment related skin toxicity, allergic reaction to the adhesive or to the gel, overheating of the array leading to pain and/or local skin burns, infections at the site where the arrays make contact with the skin, local warmth and tingling sensation beneath the arrays, medical device site reaction, muscle twitching, and skin breakdown or skin ulcer. 

 

If the patient has an underlying serious skin condition on the chest, evaluate whether this may prevent or temporarily interfere with Optune Lua treatment.

 

Indication For Use

Optune Lua is intended as a treatment concurrent with PD-1/PD-L1 inhibitors or docetaxel for adult patients with metastatic non-small cell lung cancer who have progressed on or after a platinum-based regimen. 

 


Please see full Instructions For Use (IFU) and Patient Information and Operation Manual (PIOM) for Optune Lua®.

Important Safety Information 

Contraindications 

Do not use Optune Lua® in patients with an electrical implant. Use of Optune Lua together with electrical implants has not been tested and may lead to malfunctioning of the implanted device. 

 

Do not use Optune Lua in patients known to be sensitive to conductive hydrogels. In this case, skin contact with the gel used with Optune Lua may commonly cause increased redness and itching, and rarely may even lead to severe allergic reactions, such as a fall in blood pressure and breathing difficulty.

Warnings and Precautions 

Optune Lua can only be prescribed by a healthcare provider that has completed the required certification training provided by Novocure® (the device manufacturer). 

 

Do not prescribe Optune Lua for patients who are pregnant, whom you think might be pregnant, or who are trying to get pregnant, as the safety and effectiveness of Optune Lua in these populations have not been established. 

 

The most common (≥10%) adverse events involving Optune Lua concurrent with PD-1/PD-L1 inhibitors or docetaxel were dermatitis, musculoskeletal pain, fatigue, anemia, dyspnea, nausea, cough, diarrhea, anorexia, pruritus, leukopenia, pneumonia, respiratory tract infection, localized edema, rash, pain, constipation, skin ulcers, and hypokalemia. 

 

Other potential adverse effects associated with the use of Optune Lua include treatment related skin toxicity, allergic reaction to the adhesive or to the gel, overheating of the array leading to pain and/or local skin burns, infections at the site where the arrays make contact with the skin, local warmth and tingling sensation beneath the arrays, medical device site reaction, muscle twitching, and skin breakdown or skin ulcer. 

 

If the patient has an underlying serious skin condition on the chest, evaluate whether this may prevent or temporarily interfere with Optune Lua treatment.

 

Indication For Use

Optune Lua is intended as a treatment concurrent with PD-1/PD-L1 inhibitors or docetaxel for adult patients with metastatic non-small cell lung cancer who have progressed on or after a platinum-based regimen. 

 


Please see full Instructions For Use (IFU) and Patient Information and Operation Manual (PIOM) for Optune Lua®.

Novocure Websites

This website is intended for US healthcare professionals seeking information on Optune Lua.

 

 

 

 

External links

OptuneGioHCP.com
OptuneLuaHCP.com/MPM
Novocuretrials.com

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US-OPL-00070 v1.0 November 2024